In the background, you'll notice the courthouse. To the right of that, you'll see the Adams Mark St. Louis hotel. Notice how, in the top right, there's a blurry sign about one story high.
In this much larger photo of the St. Louis skyline, that same sign is clearly about four stories high. In every photo I can find of that hotel, the sign is four stories high instead of the one story high in the Obama story. Now I'm a strong Obama supporter, so you know this isn't some strange wing-nut conspiracy thing, but why is there such a large discrepancy? Is this new? Does anyone who reads this both live in St. Louis and is in a position to verify that this sign has changed?
Update: Whew! I feel better (well, I'm still sick, but I feel better about the photo). Apparently it's now the Hyatt hotel and the image Exif data tends to support this.