Mechanical

Pre-Training: Day off

Today is scheduled for another 3 mile run but I'm skipping as I'm having problems with my left ankle. It doesn't seem to want to heal and, at worst, it's tough to walk on. Lots of ice and ibuprofen seem to be helping, but only temporarily. I think if I give it a rest until Monday, I should be fine.

This is bugging me. I can't quite seem to shake the injuries from my left leg. This is different from the knee and hip issues I was having and definitely not the same thing as the calf issues I was having. It's bugging the hell out of me because this leg just won't fucking cooperate. It's tough to run with a limp.
  • Current Mood: frustrated frustrated
  • Current Music: Yello | Vicious Games
Actually, there are (or were) a few references specifically about the effect of NSAIDs on healing, which started a lot earler than I had thought -- seems like journal articles were appearing as early as 1996. Unfortunately when I've tried to find those supposedly available on line most of them come up 404.

References, anyway:
Butcher C K, March D R. "Non-steroidal anti-inflammatory drugs delay tibial fracture healing." Injury 1996; 27: 375.

Allami MK, Giannoudis PV. "Cox inhibitors and bone healing." Acta Orthop Scand. 2003 Dec;74(6):771-2.

Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, Motilva V. "Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor." Eur J Pharmacol. 2004 Nov 28;505(1-3):187-94.
(Ibuprofen was specifically the Cox-2 inhibitor tested in this paper, and it is probably the paper I was thinking of.)

Tarnawski AS, Jones MK. "Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications." J Mol Med. 2003 Oct;81(10):627-36. Epub 2003 Sep 6.
--This last is a key paper, and points toward the way that ibuprofen inhibits inflammation being involved both in its prevention of healing and in inhibition of cancer. It's actually fascinating stuff!